Jann N Sarkaria Selected Research

Mitogen-Activated Protein Kinases

1/2019	Brain Distribution and Active Efflux of Three panRAF Inhibitors: Considerations in the Treatment of Melanoma Brain Metastases.
1/2018	Phase 1/2 trial of temsirolimus and sorafenib in the treatment of patients with recurrent glioblastoma: North Central Cancer Treatment Group Study/Alliance N0572.
1/2018	Brain Distribution of a Novel MEK Inhibitor E6201: Implications in the Treatment of Melanoma Brain Metastases.
2/2016	Factors Influencing the Central Nervous System Distribution of a Novel Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitor GSK2126458: Implications for Overcoming Resistance with Combination Therapy for Melanoma Brain Metastases.
8/2014	Factors influencing the CNS distribution of a novel MEK-1/2 inhibitor: implications for combination therapy for melanoma brain metastases.

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Jann N Sarkaria Research Topics

Disease

147	Neoplasms (Cancer) 05/2024 - 12/2002
126	Glioblastoma (Glioblastoma Multiforme) 05/2024 - 12/2002
43	Glioma (Gliomas) 11/2023 - 12/2002
41	Brain Neoplasms (Brain Tumor) 01/2024 - 01/2003
12	Breast Neoplasms (Breast Cancer) 10/2022 - 10/2012
9	Melanoma (Melanoma, Malignant) 01/2024 - 08/2014
7	Astrocytoma (Pilocytic Astrocytoma) 01/2023 - 12/2008
7	Ataxia Telangiectasia (Louis Bar Syndrome) 10/2022 - 01/2002
5	Neoplasm Metastasis (Metastasis) 01/2024 - 10/2010
5	Carcinogenesis 06/2015 - 12/2004
4	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 12/2022 - 08/2007
3	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/2023 - 06/2008
3	Hypoxia (Hypoxemia) 01/2022 - 01/2018
2	Colorectal Neoplasms (Colorectal Cancer) 04/2022 - 01/2021
2	Pancreatic Neoplasms (Pancreatic Cancer) 10/2021 - 04/2015
2	Multiple Myeloma 01/2021 - 04/2014
2	Lung Neoplasms (Lung Cancer) 01/2021 - 08/2007
2	Hematologic Neoplasms (Hematological Malignancy) 01/2021 - 10/2018
2	Oligodendroglioma 07/2019 - 07/2019
2	Infections 10/2018 - 11/2010

Drug/Important Bio-Agent (IBA)

47	Temozolomide (Temodar)FDA LinkGeneric 11/2023 - 09/2007
29	Proteins (Proteins, Gene)FDA Link 01/2023 - 12/2008
19	Phosphotransferases (Kinase)IBA 01/2023 - 01/2002
18	ErbB Receptors (EGF Receptor)IBA 01/2023 - 01/2003
12	DNA (Deoxyribonucleic Acid)IBA 01/2024 - 05/2008
11	epidermal growth factor receptor VIIIIBA 01/2021 - 03/2007
10	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 01/2019 - 10/2012
8	Biomarkers (Surrogate Marker)IBA 09/2023 - 04/2006
8	Erlotinib Hydrochloride (CP 358,774)FDA Link 01/2023 - 03/2007
8	TOR Serine-Threonine KinasesIBA 01/2018 - 01/2002
7	Poly(ADP-ribose) Polymerase InhibitorsIBA 11/2023 - 02/2009
6	Radiation-Sensitizing AgentsIBA 02/2024 - 09/2009
6	RNA (Ribonucleic Acid)IBA 01/2023 - 01/2018
5	Hyaluronic Acid (Hyaluronan)IBA 01/2024 - 11/2017
5	Amino Acids FDA Link 01/2023 - 03/2007
5	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2020 - 08/2014
5	Mitogen-Activated Protein KinasesIBA 01/2019 - 08/2014
5	Alkylating AgentsIBA 01/2019 - 05/2008
4	LigandsIBA 01/2024 - 04/2016
4	MethyltransferasesIBA 11/2023 - 09/2009
4	Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA 01/2023 - 01/2018
4	HydrogelsIBA 01/2022 - 11/2017
4	DNA-Activated Protein KinaseIBA 01/2022 - 02/2011
4	EnzymesIBA 10/2021 - 03/2017
4	Tyrosine (L-Tyrosine)FDA Link 01/2021 - 12/2011
4	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 01/2021 - 04/2005
4	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 11/2020 - 01/2013
4	Dasatinib (BMS 354825)FDA Link 10/2020 - 10/2012
4	Everolimus FDA Link 10/2020 - 06/2008
4	Sirolimus (Rapamycin)FDA Link 01/2018 - 12/2002
4	Guanine Nucleotide Exchange Factors (Guanine Nucleotide Exchange Factor)IBA 03/2016 - 12/2011
3	Immunoconjugates (Immunoconjugate)IBA 05/2024 - 12/2021
3	depatuxizumab mafodotinIBA 05/2024 - 12/2021
3	ParaffinIBA 01/2023 - 10/2017
3	GelatinIBA 01/2022 - 10/2019
3	LuciferasesIBA 01/2022 - 09/2007
3	Bevacizumab (Avastin)FDA Link 11/2020 - 01/2013
3	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 11/2019 - 06/2008
3	Tyrosine Kinase InhibitorsIBA 10/2019 - 11/2017
3	Phosphoric Monoester Hydrolases (Phosphatases)IBA 10/2019 - 12/2008
3	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 01/2018 - 02/2016
3	temsirolimus FDA Link 01/2018 - 11/2010
3	palbociclibIBA 11/2016 - 07/2012
3	veliparibIBA 05/2016 - 02/2009
3	Small Interfering RNA (siRNA)IBA 03/2016 - 02/2012
3	src-Family KinasesIBA 11/2015 - 02/2012
2	AZD1390IBA 02/2024 - 10/2022
2	peposertibIBA 01/2024 - 01/2022
2	lysyl- arginyl- alanyl- lysyl- alanyl- lysyl- threonyl- threonyl- lysyl- lysyl- arginine (PKCS)IBA 01/2024 - 01/2017
2	Reactive Oxygen Species (Oxygen Radicals)IBA 12/2023 - 01/2014
2	Guanosine Triphosphate (GTP)IBA 10/2023 - 04/2023
2	alpha-hydroxyglutarateIBA 01/2023 - 01/2018
2	dabrafenibIBA 04/2022 - 08/2014
2	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 10/2013
2	TransposasesIBA 01/2022 - 10/2021
2	salicylhydroxamic acid (SHAM)IBA 01/2022 - 01/2020
2	Firefly LuciferasesIBA 01/2022 - 01/2009
2	berzosertibIBA 12/2021 - 11/2018
2	Cisplatin (Platino)FDA LinkGeneric 12/2021 - 08/2007
2	Protein Kinases (Protein Kinase)IBA 11/2021 - 10/2005
2	Neuropilin-1IBA 12/2020 - 11/2020
2	Hormones (Hormone)IBA 10/2020 - 03/2017
2	SteroidsIBA 10/2020 - 01/2016
2	PT2385IBA 01/2020 - 01/2018
2	Protein Isoforms (Isoforms)IBA 12/2019 - 01/2016
2	SAR405838IBA 12/2019 - 01/2018
2	Formaldehyde (Formol)FDA Link 11/2019 - 10/2017
2	TensinsIBA 10/2019 - 12/2008
2	Imatinib Mesylate (Gleevec)FDA Link 07/2019 - 07/2019
2	vandetanib (ZD6474)IBA 01/2019 - 04/2010
2	Thromboplastin (Tissue Factor)IBA 01/2019 - 04/2015
2	Gefitinib (Iressa)FDA Link 01/2019 - 04/2016
2	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 11/2018 - 11/2017

Therapy/Procedure

75	Therapeutics 05/2024 - 01/2003
26	Radiotherapy 12/2022 - 12/2002
24	Drug Therapy (Chemotherapy) 11/2022 - 01/2003
3	Chemoradiotherapy 11/2023 - 11/2010
3	Immunotherapy 01/2021 - 09/2017
2	Proton Therapy 12/2022 - 01/2018
2	Lasers (Laser) 01/2019 - 12/2015